Robert Chang (rchang6)

Robert Chang

Associate Professor and Associate Chair for Graduate Studies in the Department of Mechanical Engineering

Charles V. Schaefer, Jr. School of Engineering and Science

Department of Mechanical Engineering

Edwin A. Stevens Hall 324
(201) 216-8301
(201) 216-8315
Website

Research

Additive Biomanufacturing

Biofabrication

Computer-Aided Tissue Engineering

Biomimetic Tissue-Based Design

Microscale In vitro Physiological/Pathological Systems

Mechanobiology

Experience

9/19-present, Associate Professor, Department of Mechanical Engineering, Stevens Institute of Technology, Hoboken, NJ

8/12-8/19, Assistant Professor, Department of Mechanical Engineering, Stevens Institute of Technology, Hoboken, NJ

7/11-8/12, Biomechanical Engineer, Division of Radiation and Biomolecular Physics, Physical Measurement Lab, National Institute of Standards and Technology, Gaithersburg, MD

7/09-7/11, NRC Postdoctoral Fellow, Division of Optical Technology, Physical Measurement Lab, National Institute of Standards and Technology, Gaithersburg, MD

12/04-7/09, Graduate Research Assistant, Computer-Aided Tissue Engineering Lab, Drexel University, Philadelphia, PA

Institutional Service

  • Academic Job Search Chair
  • Associate Chair of Graduate Studies Chair
  • SES Graduate Committee Member
  • PhD Qualifying Exam - CCT Committee Chair
  • Stevens CAREER Club Member
  • PhD Coordinator Chair
  • PhD Qualifying Exam - RCT Committee Chair
  • SES Doctoral Committee Member
  • Mechanical Engineering Graduate Committee Chair
  • ME and Strategic Initiatives Committee Member
  • ME PhD Student Research Seminar Chair

Professional Service

  • Macromolecular Materials and Engineering Editorial Board Member
  • Journal of Manufacturing Science and Engineering Associate Editor
  • International Journal of Bioprinting Special Issue Editor
  • Micromachines Journal Editorial Board Editorial Board Member
  • National Science Foundation - CAREER Program Panel Reviewer
  • National Science Foundation - Advanced Manufacturing Program Panel Reviewer
  • ARMI Biofab USA Leadership Advisor Council
  • ASME MSEC Symposium Organizer Manufacturing Science and Engineering Conference Symposium Organizer
  • ASME MED MSEC Conference Session Chair
  • Biofabrication Journal Special Issue Editor Special Issue Editor
  • Biomanufacturing Technical Committee Chair

Honors and Awards

NSF Faculty Early Career Development (CAREER) award, 2016

Sigma Xi NIST Best Poster Award in Mathematics and Engineering, 2011

National Research Council (NRC) Postdoctoral Associateship Award, 2009

Drexel’s Best Dissertation Award in Mathematics and Engineering, 2009

Drexel’s Graduate Research Award, 2009

NASA Tech Brief Award, 2009

NSF CMMI Research and Innovation Conference Student Award, 2009

BP Young Scientists and Students Award (YSSA), 2008

NASA Technology Transfer Award, 2008

GAANN Fellowship, 2006-2007

Professional Societies

  • SPIE Member
  • ASEE Member
  • ASME Member
  • SME Member

Patents and Inventions

Patent Pending: “Bioprinting Three-Dimensional Polymeric Hydrogel Structures Onto Microscale Tissue Analog Devices for Pharmacokinetic Study,” D2027/20052 (co-inventors B Starly, J Nam, W Sun).

Patent Pending: “Micro-Organ Device,” NASA Case No. MSC-23988-1 (co-inventors S Gonda, H Holtorf, B Starly, J Nam, W Sun).

Provisional Patent Filed: “Bioprinting Cell-laden Constructs for Multicompartment Tissue Chambers,” 46528-6016-P1-US (co-inventors J Snyder , W Sun).

Provisional Patent Filed: “Multilayered Optical Tissue Phantom Using Buried Scattering Microspheres in Polymer Layers,” 61/582,858 (co-inventors C Stafford, J Hwang)

Selected Publications

Book Chapter

  1. Chang, R. (2022). Organ Printing. 3D bioprinting and nanotechnology in tissue engineering and regenerative medicine. Academic Press.
    https://books.google.com/books?hl=en&lr=&id=RXdQEAAAQBAJ&oi=fnd&pg=PP1&dq=info:NY0pszPg0UMJ:scholar.google.com&ots=V5gbVED4H_&sig=rQaz6vJLz6d_3O6rydmJSi9Bm8s#v=onepage&q&f=false.

Conference Proceeding

  1. Chang, R. (2023). Development of an open-source low-cost modular quad-extrusion 3D Bioprinter. Proceedings of the ASME 2023 18th International Manufacturing Science and Engineering Conference (vol. MSEC2023-104996).
  2. Shi, C.; Chang, R.; Leonardi, D. (2018). The Effects of Mechanical Vibration on Cellular Health in Differentiated Neuroblastoma Cells. ASME Proceedings 2018 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference (vol. DETC2018-86280). Hoboken.
    https://doi.org/10.1115/DETC2018-86280.
  3. Ding, H.; Chang, R. (2018). Bioprinting of Liquid Hydrogel Precursors in a Support Bath by Analyzing Two Key Features: Cell Distribution and Shape Fidelity. Proceedings of ASME 2018 13th International Manufacturing Science and Engineering Conference (vol. MSEC2018-6675). Hoboken.
    https://doi.org/10.1115/MSEC2018-6675.

Journal Article

  1. Chang, R. (2024). Design and Fabrication of Fibrous Spindle‐Like Constructs Using a Melt Electrohydrodynamic Writing Process. Macromolecular Materials and Engineering (pp. 2400080).
    https://doi.org/10.1002/mame.202400080.
  2. Chang, R. (2023). Gradient Biomolecular Immobilization of 3D Structured Poly‐ɛ‐caprolactone Biomaterials toward Functional Engineered Tissue. Macromolecular Materials and Engineering (12 ed., vol. 308, pp. 2300040). Wiley.
    https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mame.202300040.
  3. Xi, Y.; Choi, C.; Chang, R.; Kaper, H. J.; Sharma, P. K. (2023). Tribology of Pore Textured Hard Surfaces under Physiological Conditions: Effects of Texture Scales. Langmuir (vol. 39, pp. 6657–6665).
  4. Chang, R. (2023). Development of a Low-Cost Quad-Extrusion 3D Bioprinting System for Multi-Material Tissue Constructs. International Journal of Bioprinting (pp. 0159). AccScience Publishing.
    https://accscience.com/journal/IJB/0/0/10.36922/ijb.0159.
  5. Chang, R. (2023). Tribology of Pore-Textured Hard Surfaces under Physiological Conditions: Effects of Texture Scales. Langmuir (19 ed., vol. 39, pp. 6657-6665). American Chemical Society.
    https://pubs.acs.org/doi/full/10.1021/acs.langmuir.2c03377.
  6. Chang, R. (2023). Design, fabrication, and characterization of tubular scaffolds by way of a melt electrowriting process. Journal of Tissue Engineering (vol. 62, pp. 103383). Sage.
    https://www.sciencedirect.com/science/article/abs/pii/S2214860422007722.
  7. Chang, R. (2022). A Holistic Model for Melt Electrowritten Three-Dimensional Structured Materials Based on Residual Charge. International Journal of Bioprinting (2 ed., vol. 9, pp. 656). Whioce Publishing.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090534/.
  8. Chang, R. (2022). Analytical Interpretation of Microscale Fiber Deviation in Designing for Polymer Melt Electrohydrodynamic-Based Additive Manufacturing. Additive Manufacturing (vol. 58, pp. 103035). Elsevier.
    https://www.sciencedirect.com/science/article/abs/pii/S2214860422004274.
  9. Chang, R. (2022). Effects of Printing Sequence on the Printing Accuracy of Melt Electrowriting Scaffolds. Macromolecular Materials and Engineering (pp. 2200222). Wiley.
    https://onlinelibrary.wiley.com/doi/abs/10.1002/mame.202200222.
  10. Chang, R. (2022). Effects of scaffold design parameters on the printing accuracy for melt electrowriting. Journal of Manufacturing Processes (vol. 81, pp. 177-190). Elsevier.
    https://doi.org/10.1016/j.jmapro.2022.06.070.
  11. Chang, R. (2022). Advancing a real-time image-based jet lag tracking methodology for optimizing print parameters and assessing melt electrowritten fiber quality. Additive Manufacturing (vol. 54, pp. 102764). Elsevier.
    https://www.sciencedirect.com/science/article/pii/S2214860422001683?via%3Dihub.
  12. Chang, R.. A review of the structural and physical properties that govern cell interactions with structured biomaterials enabled by additive manufacturing. A review of the structural and physical properties that govern cell interactions with structured biomaterials enabled by additive manufacturing (e00201 ed., vol. 26). Elsevier.
    https://doi.org/10.1016/j.bprint.2022.e00201.
  13. Chang, R. (2022). Numerical analysis on the effects of microfluidic-based bioprinting parameters on the microfiber geometrical outcomes. Scientific Reports (1 ed., vol. 12, pp. 1-16). Nature.
    https://www.nature.com/articles/s41598-022-07392-0.
  14. Chang, R. (2022). Design, fabrication, and analysis of spatially heterogeneous scaffold by melt electrospinning writing of poly (ε‐ Caprolactone). Journal of Applied Polymer Science (22 ed., vol. 139, pp. 52235).
    https://doi.org/10.1002/app.52235.
  15. Chang, R. (2021). A Charge‐Based Mechanistic Study into the Effect of Collector Temperature on Melt Electrohydrodynamic Printing Outcomes. Advanced Materials Technologies (pp. 2100251). Wiley.
    https://onlinelibrary.wiley.com/doi/abs/10.1002/admt.202100251.
  16. Chang, R. C. (2020). A Charge-Based Mechanistic Study into the Effects of Process Parameters on Fiber Accumulating Geometry for a Melt Electrohydrodynamic Process. Processes (11 ed., vol. 8, pp. 1440).
    https://www.mdpi.com/2227-9717/8/11/1440.
  17. Chang, R.. Biomedical Manufacturing: A Review of the Emerging Research and Applications. Journal of Manufacturing Science and Engineering (11 ed., vol. 142).
  18. Chang, R. (2019). 3D Bioprinted GelMA Based Models for the Study of Trophoblast Cell Invasion. Scientific Reports (1 ed., vol. 9, pp. 1-13).
  19. Ding, H.; Cao, K.; Zhang, F.; Boettcher, W.; Chang, R. C. (2019). A Fundamental Study of Charge Effects on Melt Electrowritten Polymer Fibers. Materials & Design (vol. 178). Hoboken.
    https://doi.org/10.1016/j.matdes.2019.107857.
  20. Tourlomousis, F.; Jia, C.; Mershin, A.; Karydis, T.; Wang, H.; Kalyon, D.; Chang, R. C. (2019). Machine learning metrology of cell confinement in melt electrowritten three-dimensional biomaterial substrates. Nature Microsystems & Nanoengineering (1 ed., vol. 5). Hoboken.
    1 Castle Point on Hudson.
  21. Palumbo, A.; Tourlomousis, F.; Chang, R.; Yang, E. (2018). Influence of Transition Metal Dichalcogenide Surfaces on Cellular Morphology and Adhesion. ACS Applied Bio Materials. ACS Applied Bio Materials (5 ed., vol. 1, pp. 1448--1457). American Chemical Society.
  22. Ding, H. C.; Chang, R. C. (2018). Simulating image-guided in situ bioprinting of a skin graft onto a phantom burn wound bed. Additive Manufacturing (vol. 22, pp. 708-719). Hoboken.
    https://doi.org/10.1016/j.addma.2018.06.022.
  23. Ding, H.; Chang, R. C. (2018). Hyperspectral Imaging With Burn Contour Extraction for Burn Wound Depth Assessment. ASME Journal of Engineering and Science in Medical Diagnostics (4 ed., vol. 1, pp. 041002). Hoboken.
    https://doi.org/10.1115/1.4040470.
  24. Tourlomousis, F.; Ding, H.; Kalyon, D.; Chang, R. (2017). Melt electrospinning writing process guided by a "Printability Number". Journal of Manufacturing Science and Engineering, Transactions of the ASME (8 ed., vol. 139).
  25. Chang, R. (2002). Quantitative Investigation into the Design and Process Parametric Effects on the Fiber‐Entrapped Residual Charge for a Polymer Melt Electrohydrodynamic Printing Process. Macromolecular Materials and Engineering (3 ed., vol. 307, pp. 2100766). Wiley.
    https://doi.org/10.1002/mame.202100766.

US Patent