Carrie Perlman
Associate Professor
Charles V. Schaefer, Jr. School of Engineering and Science
Department of Biomedical Engineering
Research
In the Lung Mechanics Laboratory, Dr. Perlman and her group combine mechanics, physiology and biophysics to understand and develop new treatments for ventilation injury of edematous lungs.
Openings are available for talented and enthusiastic individuals to join the lab in the position of staff researcher, postdoctoral fellow and/or Ph.D. student. Please email Dr. Perlman, including a copy of your CV, to inquire.
Openings are available for talented and enthusiastic individuals to join the lab in the position of staff researcher, postdoctoral fellow and/or Ph.D. student. Please email Dr. Perlman, including a copy of your CV, to inquire.
General Information
Dr. Perlman's activities include teaching an undergraduate biotransport course, teaching a graduate cardiopulmonary mechanics and physiology course and directing the Stevens BME Ph.D. program. She has served on NIH study sections and is chair of an American Thoracic Society committee that reviews research and clinical project proposals.
Experience
Education:
B.S.M.E., Mechanical Engineering, MIT
M.S., Ph.D., Biomedical Engineering, Northwestern University
Postdoctoral training, Physiology & Cellular Biophysics and Pulmonary Division, Dept of Medicine, Columbia University
Publications:
Ansari Z, Battikha J, Singh C, Perlman CE. Alveolar distribution of nebulized solution in health and lung injury assessed by confocal microscopy. Physiological Reports, In press.
Perlman CE, Knudsen L, Smith BJ. The fix is not yet in: recommendation for fixation of lungs within physiological/pathophysiological volume range in pulmonary structure-function studies. American Journal of Physiology - Lung Cellular and Molecular Physiology 327: L218 - L231, 2024.
Knudsen L, Hummel B, Wrede C, Zimmermann R, Perlman CE, Smith BJ. Acinar micromechanics in health and lung injury: what we have learned from quantitative morphology. Frontiers in Physiology 14: 1142221, 2023.
Kulkarni HS, Lee JS, Bastarche JA et al. Update on the features and measurements of experimental acute lung injury in animals: an official American Thoracic Society workshop report. American Journal of Respiratory Cell and Molecular Biology 66: e1 - e14, 2022.
Wu Y, Nguyen T, Perlman CE. Intravenous sulforhodamine B reduces alveolar surface tension, improves oxygenation and reduces ventilation-induced lung injury in a respiratory distress model. Journal of Applied Physiology 130: 1305-1316, 2021.
Nguyen T, Perlman CE. Sulforhodamine B and exogenous surfactant effects on alveolar surface tension under acute respiratory distress syndrome conditions. Journal of Applied Physiology 129: 1505-1513, 2020.
Jardim-Neto A.C., Perlman C.E. A low-cost off-the-shelf pressure-controlled mechanical ventilator for a mass respiratory failure scenario. British Journal of Anesthesia 125: e438-e440, 2020.
Perlman CE. The contribution of surface tension-dependent alveolar septal stress concentrations to ventilation-induced lung injury in the acute respiratory distress syndrome. Frontiers in Physiology, 11: 388, 2020.
Albert RK, Smith B, Perlman CE, Schwartz DA. Is Progression of Pulmonary Fibrosis due to Ventilation-induced Lung Injury? American Journal of Respiratory and Critical Care Medicine, 200: 140-151, 2019.
Nguyen TL, Perlman CE. Tracheal acid or surfactant instillation raises alveolar surface tension. Journal of Applied Physiology, 125: 1357-1367, 2018.
Wu, Y, Nguyen TL, Perlman CE. Accelerated deflation promotes homogeneous airspace liquid redistribution in the edematous lung. Journal of Applied Physiology 122:739-751, 2017.
Kharge AB, Wu Y, Perlman CE. Sulforhodamine B interacts with albumin to lower surface tension and protect against ventilation injury of flooded alveoli. Journal of Applied Physiology 118: 355-364, 2015.
Perlman CE. Letter to the Editor: On modeling edematous alveolar mechanics. Journal of Applied Physiology 117: 937, 2014.
Wu Y, Kharge AB, Perlman CE. Lung ventilation injures areas with discrete alveolar flooding, in a surface-tension dependent fashion. Journal of Applied Physiology 117: 788-796, 2014.
Kharge AB, Wu Y, Perlman CE. Surface tension in situ in flooded alveolus unaltered by albumin. Journal of Applied Physiology 117: 440-451, 2014.
Perlman CE, Wu Y. In situ determination of alveolar septal strain, stress and effective Young’s modulus: an experimental/computational approach. American Journal of Physiology - Lung Cellular & Molecular Physiology 307: L302-L310, 2014.
Perlman CE, Mockros LF. Predicted oxygenation efficacy of a thoracic artificial lung. American Society for Artificial Internal Organs (ASAIO) Journal 58: 247-254, 2012.
Wu Y, Perlman CE. In situ methods for assessing alveolar mechanics. Journal of Applied Physiology 112: 519-526, 2012.
Perlman CE, Lederer DJ, Bhattacharya J. Micromechanics of alveolar edema. American Journal of Respiratory Cell and Molecular Biology 44: 43-39, 2011.
Bhattacharya J, Perlman CE. Letter to the Editor: Commentaries on Viewpoint--Standards for quantitative assessment of lung structure. Air space connectivity. Journal of Applied Physiology 109: 935-936, 2010.
Kuo AS, Perlman CE, Mockros LF, Cook KE. Pulmonic valve function during thoracic artificial lung attachment. American Society for Artificial Internal Organs (ASAIO) Journal 54: 197-202, 2008.
Perlman CE, Bhattacharya J. Alveolar expansion imaged by optical sectioning microscopy. Journal of Applied Physiology 103: 1037-1044, 2007.
Lindert J, Perlman CE, Parthasarathi K, Bhattacharya J. Chloride-dependent secretion of alveolar wall liquid determined by optical sectioning microscopy. American Journal of Respiratory Cell and Molecular Biology 36: 688-696, 2007.
Perlman CE, Mockros LF. Hemodynamic consequences of thoracic artificial lung attachment configuration: a computational model. ASAIO American Society for Artificial Internal Organs (ASAIO) Journal 53: 50-64, 2007.
Perlman CE, Cook KE, Seipelt R, Mavroudis C, Backer CL, Mockros LF. In vivo hemodynamic responses to thoracic artificial lung attachment. American Society for Artificial Internal Organs (ASAIO) Journal 51: 412-25, 2005.
Cook KE, Perlman CE, Seipelt R, Backer CL, Mavroudis C, Mockros LF. Hemodynamic and gas transfer properties of a compliant thoracic artificial lung. American Society for Artificial Internal Organs (ASAIO) Journal 51: 404-11, 2005.
Boschetti F, Cook KE, Perlman CE, Mavroudis LF, Backer CL, Mockros LF. Blood flow pulsatility effects upon oxygen transfer in artificial lungs. American Society for Artificial Internal Organs (ASAIO) Journal 49: 678-686, 2003.
Boschetti F, Perlman CE, Cook KE, Mockros LF. Hemodynamic effects of attachment modes and device design of a thoracic artificial lung. American Society for Artificial Internal Organs (ASAIO) Journal 46: 42-48, 2000.
B.S.M.E., Mechanical Engineering, MIT
M.S., Ph.D., Biomedical Engineering, Northwestern University
Postdoctoral training, Physiology & Cellular Biophysics and Pulmonary Division, Dept of Medicine, Columbia University
Publications:
Ansari Z, Battikha J, Singh C, Perlman CE. Alveolar distribution of nebulized solution in health and lung injury assessed by confocal microscopy. Physiological Reports, In press.
Perlman CE, Knudsen L, Smith BJ. The fix is not yet in: recommendation for fixation of lungs within physiological/pathophysiological volume range in pulmonary structure-function studies. American Journal of Physiology - Lung Cellular and Molecular Physiology 327: L218 - L231, 2024.
Knudsen L, Hummel B, Wrede C, Zimmermann R, Perlman CE, Smith BJ. Acinar micromechanics in health and lung injury: what we have learned from quantitative morphology. Frontiers in Physiology 14: 1142221, 2023.
Kulkarni HS, Lee JS, Bastarche JA et al. Update on the features and measurements of experimental acute lung injury in animals: an official American Thoracic Society workshop report. American Journal of Respiratory Cell and Molecular Biology 66: e1 - e14, 2022.
Wu Y, Nguyen T, Perlman CE. Intravenous sulforhodamine B reduces alveolar surface tension, improves oxygenation and reduces ventilation-induced lung injury in a respiratory distress model. Journal of Applied Physiology 130: 1305-1316, 2021.
Nguyen T, Perlman CE. Sulforhodamine B and exogenous surfactant effects on alveolar surface tension under acute respiratory distress syndrome conditions. Journal of Applied Physiology 129: 1505-1513, 2020.
Jardim-Neto A.C., Perlman C.E. A low-cost off-the-shelf pressure-controlled mechanical ventilator for a mass respiratory failure scenario. British Journal of Anesthesia 125: e438-e440, 2020.
Perlman CE. The contribution of surface tension-dependent alveolar septal stress concentrations to ventilation-induced lung injury in the acute respiratory distress syndrome. Frontiers in Physiology, 11: 388, 2020.
Albert RK, Smith B, Perlman CE, Schwartz DA. Is Progression of Pulmonary Fibrosis due to Ventilation-induced Lung Injury? American Journal of Respiratory and Critical Care Medicine, 200: 140-151, 2019.
Nguyen TL, Perlman CE. Tracheal acid or surfactant instillation raises alveolar surface tension. Journal of Applied Physiology, 125: 1357-1367, 2018.
Wu, Y, Nguyen TL, Perlman CE. Accelerated deflation promotes homogeneous airspace liquid redistribution in the edematous lung. Journal of Applied Physiology 122:739-751, 2017.
Kharge AB, Wu Y, Perlman CE. Sulforhodamine B interacts with albumin to lower surface tension and protect against ventilation injury of flooded alveoli. Journal of Applied Physiology 118: 355-364, 2015.
Perlman CE. Letter to the Editor: On modeling edematous alveolar mechanics. Journal of Applied Physiology 117: 937, 2014.
Wu Y, Kharge AB, Perlman CE. Lung ventilation injures areas with discrete alveolar flooding, in a surface-tension dependent fashion. Journal of Applied Physiology 117: 788-796, 2014.
Kharge AB, Wu Y, Perlman CE. Surface tension in situ in flooded alveolus unaltered by albumin. Journal of Applied Physiology 117: 440-451, 2014.
Perlman CE, Wu Y. In situ determination of alveolar septal strain, stress and effective Young’s modulus: an experimental/computational approach. American Journal of Physiology - Lung Cellular & Molecular Physiology 307: L302-L310, 2014.
Perlman CE, Mockros LF. Predicted oxygenation efficacy of a thoracic artificial lung. American Society for Artificial Internal Organs (ASAIO) Journal 58: 247-254, 2012.
Wu Y, Perlman CE. In situ methods for assessing alveolar mechanics. Journal of Applied Physiology 112: 519-526, 2012.
Perlman CE, Lederer DJ, Bhattacharya J. Micromechanics of alveolar edema. American Journal of Respiratory Cell and Molecular Biology 44: 43-39, 2011.
Bhattacharya J, Perlman CE. Letter to the Editor: Commentaries on Viewpoint--Standards for quantitative assessment of lung structure. Air space connectivity. Journal of Applied Physiology 109: 935-936, 2010.
Kuo AS, Perlman CE, Mockros LF, Cook KE. Pulmonic valve function during thoracic artificial lung attachment. American Society for Artificial Internal Organs (ASAIO) Journal 54: 197-202, 2008.
Perlman CE, Bhattacharya J. Alveolar expansion imaged by optical sectioning microscopy. Journal of Applied Physiology 103: 1037-1044, 2007.
Lindert J, Perlman CE, Parthasarathi K, Bhattacharya J. Chloride-dependent secretion of alveolar wall liquid determined by optical sectioning microscopy. American Journal of Respiratory Cell and Molecular Biology 36: 688-696, 2007.
Perlman CE, Mockros LF. Hemodynamic consequences of thoracic artificial lung attachment configuration: a computational model. ASAIO American Society for Artificial Internal Organs (ASAIO) Journal 53: 50-64, 2007.
Perlman CE, Cook KE, Seipelt R, Mavroudis C, Backer CL, Mockros LF. In vivo hemodynamic responses to thoracic artificial lung attachment. American Society for Artificial Internal Organs (ASAIO) Journal 51: 412-25, 2005.
Cook KE, Perlman CE, Seipelt R, Backer CL, Mavroudis C, Mockros LF. Hemodynamic and gas transfer properties of a compliant thoracic artificial lung. American Society for Artificial Internal Organs (ASAIO) Journal 51: 404-11, 2005.
Boschetti F, Cook KE, Perlman CE, Mavroudis LF, Backer CL, Mockros LF. Blood flow pulsatility effects upon oxygen transfer in artificial lungs. American Society for Artificial Internal Organs (ASAIO) Journal 49: 678-686, 2003.
Boschetti F, Perlman CE, Cook KE, Mockros LF. Hemodynamic effects of attachment modes and device design of a thoracic artificial lung. American Society for Artificial Internal Organs (ASAIO) Journal 46: 42-48, 2000.
Institutional Service
- BME Department/General Member